Date: 2005.2.1 (Wed) 13:00-14:15
Place: General Research Building, Room 663
Speaker: Koji Jimura
Title: Dissociable concurrent activity in lateral and medial prefrontal cortex during external feedback processing
Keywords: prefrontal cortex, cognition, emotion, external feedback, fMRI

Affiliation: Department of Physiology, Graduate School of Medicine
Position: Graduate Student
Adviser: Yasushi Miyashita, Miyashita Lababoratory
Disciplines: Cognitive neuroscience
Societies and Conferences: Society for neuroscience, Cognitive neuroscience society, Cognitive science society, Organization for human brain mapping, American Psychological Association

Bibliography: Koji Jimura, Dissociable concurrent activity in lateral and medial prefrontal cortex during external feedback processing, Human Science Integration Seminar Abstracts, No. 15, pp. 1, 2006.
(Please use this bibliography when you cite this abstract.)

Abstract:
Flexible adaptation to changing environment, one of the representative functions of the prefrontal cortex, is often guided by external feedback on results of one’s behavior. The prefrontal cortex can be divided into two parts, the lateral and medial, traditionally held to have dissociable mental functions: the lateral part is considered to subserve various cognitive functions, while the medial part is considered to subserve social aspects of behavior such as emotion. In the present fMRI study, multiple mental components evoked by the presentation of negative feedback were dissociated along the cognitive-emotional axis in a set-shifting paradigm. The double dissociation of concurrent feedback-related activity was observed in the right prefrontal cortex: the lateral prefrontal cortex was associated with the inferential component, whereas the medial prefrontal cortex was associated with the emotional component. The medial prefrontal regions were also activated in a confirmatory experiment in which negative feedback was presented in a simpler situation. The double dissociation in the right prefrontal cortex suggests that the lateral and medial prefrontal cortex cooperatively but differentially contributes to the negative feedback processing, demonstrating the lateral/medial dichotomy of the prefrontal cortex functions suggested by previous neuropsychological studies.

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