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2005-09-21: Human SCINT Seminar (10) - 2
Poster Mihoko Otake  Registed 2005-12-26 18:00 (1259 hits)

Date: 2005.9.21 (Wed) 15:30-17:45
Place: General Research Building, Room 630
Time: 16:45-17:45
Speaker: Jun Suzurikawa
Title: The plasticity in brain and reorganization of the neural network with it
Keywords: plasticity, microstimulation, self-organization, auditory cortex, visual cortex

Affiliation: Department of Engineering Synthesis, Graduate School of Engineering
Position: Graduate Student
Adviser: Shin'ich Warisawa, Mitsuishi & Warisawa Laboratory
Disciplines: microfabrication, electrophysiology, neural engineering
Societies and Conferences: The Japan Society for Precision Engineering, Japanese Society for Medical and Biological Engineering, The Society of Instrument and Control Engineers, Symposium on Biological and Physiological Engineering, International IEEE EMBS Conference on Neural Engineering

Bibliography: Jun Suzurikawa, The plasticity in brain and reorganization of the neural network with it, Human Science Integration Seminar Abstracts, No. 10, pp. 2, 2005.
(Please use this bibliography when you cite this abstract.)

Synaptic plasticity is thought to undergo various functions of our brain, such as memory and learning. Recent single-cell studies, mainly carried out by M. M. Poo and his colleagues, suggested a spike time-dependent plasticity (STDP) rule, by which a relative timing between excitatory postsynaptic potentials (EPSPs) and a single postsynaptic action potential (AP) determines the direction of changes in the synaptic strength. In this presentation, we reviewed in vivo studies on STDP, which tried to modify physiological responses in sensory cortices and motor cortex by inducing either potentiation or depression, controlling precisely the timing between EPSPs and AP. Even in human motor cortex, surprisingly, transcranial magnetic stimulation (TMS) induced plastic changes attributed to STDP. We also reported our own research in rat auditory cortex, where we tried to ‘rewrite’ tuning properties by acoustic stimuli and intracortical microstimulation (ICMS). We successfully depressed the neural response to a specific frequency by controlling the relative timing between ICMS-induced APs and acoustically induced EPSPs.

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[7] Wang HX, Gerkin RC, Nauen DW, Bi GQ, “Coactivation and timing-dependent integration of synaptic potentiation and depression”, Nat. Neurosci, 8, pp. 187-193, 2005
[8] Schuett S, Bonhoeffer T, Hubener M, “Pairing-induced changes of orientation maps in cat visual cortex”, Neuron, 32, pp. 325-337, 2001
[9] Valentine PA, Eggermont JJ, “Intracortical microstimulation induced changes in spectral and temporal response properties in cat auditory cortex”, Hear. Res., 183, pp. 109-125, 2003
[10] Wolters A, et al., “A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex”, J. Neurophysiol., 89, pp. 2339-2345, 2003
[11] Yao H, Dan Y, “Stimulus timing-dependent plasticity in cortical processing of orientation”, Neuron, 32, pp. 315-323, 2001
[12] Yao H, Shen Y, Dan Y, “Intracortical mechanism of stimulus-timing-dependent plasticity in visual cortical orientation tuning”, Proc. Natl. Acad. Sci. USA, 101, pp. 5081-5086, 2004
[13] Zhou Q, Tao HW, Poo MM, “Reversal and stabilization of synaptic modifications in a developing visual system”, Science, 300, pp. 1953-1957, 2003
[14] Suzurikawa J, Hisada K, Nakao M, Kaga K, Kanzaki R, Takahashi H, “Reorganization of auditory cortex by pairing and anti-pairing intracortical microstimulation”, Proceedings of 2nd International IEEE EMBS Conference on Neural Engineering, pp. 594-597, 2005
[15] Voigt T, Opitz T, Lima AD, “Activation of early silent synapses by spontaneous synchronous network activity limits the range of neocortical connections”, J. Neurosci., 25, pp. 4605-4615, 2005
[16] Wagenaar DA, Madhavan R, Pine J, Potter SM, “Controlling bursting in cortical cultures with closed-loop multi-electrode stimulation”, J. Neurosci., 25, pp. 680-688, 2005
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