Date: 2005.9.21 (Wed) 15:30-17:45
Place: General Research Building, Room 630
Time: 16:45-17:45
Speaker: Jun Suzurikawa
Title: The plasticity in brain and reorganization of the neural network with it
Keywords: plasticity, microstimulation, self-organization, auditory cortex, visual cortex

Affiliation: Department of Engineering Synthesis, Graduate School of Engineering
Position: Graduate Student
Adviser: Shin'ich Warisawa, Mitsuishi & Warisawa Laboratory
Disciplines: microfabrication, electrophysiology, neural engineering
Societies and Conferences: The Japan Society for Precision Engineering, Japanese Society for Medical and Biological Engineering, The Society of Instrument and Control Engineers, Symposium on Biological and Physiological Engineering, International IEEE EMBS Conference on Neural Engineering

Bibliography: Jun Suzurikawa, The plasticity in brain and reorganization of the neural network with it, Human Science Integration Seminar Abstracts, No. 10, pp. 2, 2005.
(Please use this bibliography when you cite this abstract.)

Abstract:
Synaptic plasticity is thought to undergo various functions of our brain, such as memory and learning. Recent single-cell studies, mainly carried out by M. M. Poo and his colleagues, suggested a spike time-dependent plasticity (STDP) rule, by which a relative timing between excitatory postsynaptic potentials (EPSPs) and a single postsynaptic action potential (AP) determines the direction of changes in the synaptic strength. In this presentation, we reviewed in vivo studies on STDP, which tried to modify physiological responses in sensory cortices and motor cortex by inducing either potentiation or depression, controlling precisely the timing between EPSPs and AP. Even in human motor cortex, surprisingly, transcranial magnetic stimulation (TMS) induced plastic changes attributed to STDP. We also reported our own research in rat auditory cortex, where we tried to ‘rewrite’ tuning properties by acoustic stimuli and intracortical microstimulation (ICMS). We successfully depressed the neural response to a specific frequency by controlling the relative timing between ICMS-induced APs and acoustically induced EPSPs.

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