Under The National School Establishment Law, Hiroshima University was established on May 31, 1949. After World War II, the school system in Japan was entirely reformed and each of the institutions of higher education under the pre-war system was reorganized. As a general rule, one national university was established in each prefecture, and Hiroshima University became a national university under the new system by combining the various pre-war higher educational institutions in Hiroshima Prefecture.

The new university combined eight component institutions: Hiroshima University of Literature and Science, Hiroshima School of Secondary Education, Hiroshima School of Education, Hiroshima Women's School of Secondary Education, Hiroshima School of Education for Youth, Hiroshima Higher School, Hiroshima Higher Technical School, and Hiroshima Municipal Higher Technical School. Later in 1953, the Hiroshima Prefectural Medical College was also added to the new Hiroshima University.